Sripradha biography definition
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Abstract
Keywords:
ROS
Liver injury
Inflammation
Lipid peroxidation
Glutathione
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It is well known that oxidative stress plays an important role in the pathophysiology of various liver diseases, such as alcoholic liver disease (ALD),1 nonalcoholic stea-tohepatitis (NASH),2 and hepatitis type C,3 where free radicals attack to cell membranes, lipids and proteins leading to tissue injury, initially for cirrhosis and finally to hepatocellular carcinoma (HCC). However, the exact mechanisms by which oxidative stress produces hepatic injury is not yet well understood, and further studies on this topic are needed. In addition, there exist several methods to assess oxidative and nitrosative stress which deserve revision in depth to facilitate the understanding of these processes in hepatic injury. Therefore, the main objectives of this review are to discuss some aspec
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Abstract
Curcuma longae Rhizoma, commonly known as turmeric, is extensively utilized not only in Traditional Chinese medicin (TCM) but also across various traditional medicine systems worldwide. It is renowned for its effectiveness in removing blood stasis, promoting blood circulation, and relieving pain. The primary bioactive metabolites of Curcuma longae Rhizoma—curcumin, β-elemene, curcumol, and curdione—have been extensively studied for their pharmacological benefits. These include anti-tumor properties, cardiovascular and cerebrovascular protection, immune regulation, liver protection, and their roles as analgesics, anti-inflammatories, antivirals, antibacterials, hypoglycemics, and antioxidants. This review critically examines the extensive body of research regarding the mechanisms of action of Curcuma longae Rhizoma, which engages multiple molecular targets and signaling pathways such as NF-κB, MAPKs, and PI3K/AKT. The core objective of this review is to assess how the main
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Abstract
The study of medicinal plants, such as the genus Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of Garcinia gardneriana in experimental models of obesity for possible metabolic alterations. Swiss mice receiving a high-fat diet were supplemented with aqueous or ethanolic extract of G. gardneriana at doses of or mg/kg/day. It was found that there was a reduction in food consumption in experimental groups compared with the control groups, and the group supplemented with aqueous extract at a dose of mg/kg/daydisplayed a reduction in weight. The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose. G. gardneriana did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentra